Cloning and Sequence Analysis of Gene Encoding OipA from Iranian Patients with Helicobacter pylori Infection

Cloning and Sequence Analysis of Gene Encoding OipA from Iranian Clinical Helicobacter pylori

Background: Outer inflammatory protein A (OipA) is one of the important adhesins of H. pylori and a valuable candidate for vaccine development. Its gene is under "on-off" switch status which correlates with OipA protein expression. Objectives: We aimed to obtain a recombinant OipA clone (with "on" status) from an Iranian clinical isolate. Materials and Methods: A clinical H. pylori-isolate demo...

Analysis of KRAS gene mutation associated with Helicobacter pylori infection in patients with gastric cancer

Objective(s): KRAS proto-oncogene mutation can be considered a diagnostic factor for treating various malignancies. Helicobacter pylori infection, a risk factor for stomach cancer, may cause DNA damage and genetic changes. The aim of the current study was to assess the association of gastric cancer and KRAS mutation, demographic factors, and H. pylori infection.<...

(oipA) of Helicobacter pylori

MICROBIOLOGY. For the article ‘‘A Mr 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori’’ by Yoshio Yamaoka, Dong H. Kwon, and David Y. Graham, which appeared in number 13, June, 20, 2000, of Proc. Natl. Acad. Sci. USA (97, 7533–7538), the authors note the following correction. The sequence of the HP0638 gene was incorrect as published. The sequence published was 59-GCT...

Presence of cagA Gene in Patients with Gastric Cancer and Gastritis with Helicobacter pylori Infection

Background and purpose: Helicobacter pylori is a gram-negative, micro-aerophilic, and spiral-shaped bacillus. Infection with this bacterium can lead to gastritis, ulcers, and even gastric cancer. This study was conducted to evaluate the presence of the cagA gene among patients with gastritis and gastric cancer. Materials and methods: This study was performed in patients with gastritis (n=40) a...

Cloning and Expression of the Heterogenic Vacuolating Cytotoxin From an Iranian Helicobacter pylori Strain